Best Non-Toxic Body Oil in 2025
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What we look for:
- Thoughtful formulas made with natural or safe synthetic ingredients
- Free from parabens, PEGs, phthalates, harsh sulfates, BHA/BHT, artificial dyes, formaldehyde-releasing ingredients, and undisclosed synthetic fragrance (unless certified safe)
- Minimal, well-chosen preservatives
- Trusted third-party certifications when available
- Transparent sourcing, ingredient lists, and manufacturing practices
Find Non-Toxic Body Oil
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User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Organic Sweet Almond Body Oil - Sky Organics
Product Details
- Rich in skin-nourishing vitamins for long-lasting moisture with a soft, smooth, non-greasy finish.
- Formulated with a sweet, milky almond scent suitable for use all over the body, hair, feet, and cuticles.
- Hexane-free, unrefined, and cold-pressed to retain natural vitamins and antioxidants.
- Can be used as a skin-soothing massage oil, daily body oil, or in DIY beauty recipes.
- Designed to complement and enhance a clean beauty routine with minimal ingredients.
Pros & Cons
Pros
- Lightweight and non-greasy, perfect for moisturizing face and hair.
- Versatile use for skin, hair, and even cooking due to its organic nature.
- Fast absorption with no strong odor, ideal for sensitive noses.
- Great for people with sensitive skin or prone to allergies and eczema.
- Helps to heal burns and soothe skin irritation effectively.
- Stays pure with safe, chemical-free ingredients.
Cons
- A few users notice differences in ingredients and scent, potentially affecting those sensitive to changes.
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Prunus Amygdalus Dulcis (Almond) Oil*
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User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Sweet Almond Skin Care Oil - Aura Cacia
Product Details
- Deeply hydrates and softens skin with vitamin E and essential fatty acids.
- Versatile as a daily moisturizer, massage oil, or hair treatment.
- Contains only plant and mineral-based ingredients with no artificial fragrances or colors.
- Quickly absorbs into skin, making it ideal for face, body, and scalp care.
- Serves as a perfect carrier oil for blending with pure essential oils.
Pros & Cons
Pros
- Wonderful for moisturizing combination and sensitive skin without causing breakouts.
- Helps with stretch marks and eczema, even for babies.
- Lightweight, absorbs quickly, and leaves skin feeling soft and smooth.
- No toxic ingredients, great for health-conscious individuals.
- Versatile for use with essential oils or as a lotion alternative.
Cons
- Some may experience issues with the bottle leaking or being challenging to use without spills.
- One user felt it was not genuine sweet almond oil, which could concern purists.
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Organic Prunus Amygdalus Dulcis (Sweet Almond) Oil, Mixed Tocopherol (Vitamin E, Helianthus Annuus (Sunflower) Oil)
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User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Body Oil - Clary Collection
Product Details
- This light oil moisturizes your body from head to toe without leaving a greasy feel.
- Versatile use as a daily moisturizer, shaving oil, or massage oil, and can be added to bathwater.
- Contains natural ingredients like calendula, chamomile, lavender, and plantain for skin benefits.
- Ideal for newborns, children, and sensitive skin due to its calming effects on irritation and inflammation.
- Made from sustainably sourced ingredients and certified non-toxic, free from harmful additives.
Pros & Cons
Pros Mentioned
- Great
- Favorite
- Useful
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Organic Olive Oil, Organic Plantain Leaves, Organic Calendula Flowers, Organic Chamomile Flowers, Organic Lavender Flowers, Organic Rosemary Extract
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User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Organic Pure Radiance Body Oil - True Botanicals
Product Details
- Moisturizes and restores skin health for a radiant appearance.
- Formulated with all-natural and vegan ingredients for a non-toxic experience.
- Clinically proven for effectiveness and dermatologist tested for safety.
- Suitable for all skin types, offering universal benefits.
Pros & Cons
Pros
- Mixes well with other skincare products, enhancing benefits.
- Moisturizes dry skin without leaving a greasy residue.
- Natural, pleasant fragrance appreciated by most users.
- Long-lasting, feeling luxurious and refreshing on the skin.
- Absorbs swiftly and leaves skin silky smooth.
Cons
- Some users may find the sandalwood fragrance too strong.
- Glass bottle might be slippery to handle in wet conditions.
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Camellia Oleifera (Green Tea) Seed Oil*, Helianthus Annuus (Sunflower) Seed Oil*, Hemp Seed Oil*, Salvia Hispanica (Chia) Seed Oil*, Rosmarinus Officinalis (Rosemary) Leaf Extract*, Amyris Balsamifera Bark Oil, Bulnesia Sarmientoi Wood Oil, Cinnamomum Zeylanicum Leaf Oil, Citrus Aurantium Dulcis (Orange) Peel Oil, Juniperus Mexicana (Cedarwood) Oil, Pogostemon Cablin Oil, Santalum Austrocaledonicum (Sandalwood) Wood Oil, Citral, Eugenol, Limonene, Linalool *Denotes Organic Ingredient
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Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Fresh Body Oil - Qet Botanicals
Product Details
- Naturally firms and hydrates skin, leaving it soft and smooth.
- Glides effortlessly during shaving, soothing and calming the skin.
- No toxic ingredients like parabens, sulfates, or artificial fragrances.
- Locks in hydration when applied to damp skin after showering.
- Supports healthy skin with natural emollients and essential oils.
- A multi-purpose oil ideal for shaving, massaging, and showering.
Pros & Cons
Pros Mentioned
- None
Cons Mentioned
- Smelly
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Vitis Vinifera (Grape) Seed Oil*, Olea Europaea (Olive) Fruit Oil*, Helianthus Annus (Sunflower) Seed Oil*, Brassica Oleracea (Broccoli) Seed Oil, Tocopherol (Non-GMO Vitamin E), Lavandula Angustifolia (Lavender) Flower Oil*, Mentha Piperita (Peppermint) Leaf Oil*, Rubus Idaeus (Red Raspberry) Seed Oil, Rosmarinus Officinalis (Rosemary) Flower Oil*, Jasminum Sambac (Jasmine) Flower Oil* Organic Ingredient
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Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Coconut Body Oil - Annmarie
Product Details
- Herb-infused for a natural, nourishing moisturization.
- Contains extra virgin coconut oil, renowned for its hydrating properties.
- Use after shower or bath for all-over body moisturizing.
- Ideal as massage oil when warmed between palms before application.
- Non-toxic formula suitable for health-conscious individuals.
Pros & Cons
Pros
- Features a natural, chemical-free formulation.
- Delivers a delightful scent with soothing lavender notes.
- Absorbs nicely, leaving skin moisturized without excessive oiliness.
- Eco-friendly with limited plastic packaging.
- Part of the Leaping Bunny Compassionate Shopping Guide, ensuring no animal testing.
Cons
- Some users report a tricky pump that dispenses more product than needed.
- A few individuals with sensitive skin may experience irritation.
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Cocos Nucifera (Extra Virgin Coconut) Oil, Helianthus Annuus (Sunflower) Seed Oil, Herb-Infused Oil [Vitis Vinifera (Grape) Seed Oil, Calendula Officinalis (Calendula) Flower Extract, Symphytum Officinale (Comfrey) Leaf Extract, Symphytum Officinale (Comfrey) Root Extract, Echinacea Purpurea (Echinacea) Extract, Ginkgo Biloba (Gingko) Leaf Extract, Lycium Chinense (Goji Berry) Fruit Extract, Centella Asiatica (Gotu Kola) Leaf Extract, Hibiscus Sabdariffa (Hibiscus) Flower Extract, Lavandula Angustifolia (Lavender) Flower Extract, Melissa Officinalis (Lemon Balm) Leaf Extract, Glycyrrhiza Glabra (Licorice) Root Extract, Helichrysum Arenarium (Life Everlasting) Flower Extract, Nelumbo Nucifera (Lotus) Stamen Extract, Plantago Lanceolata (Plantain) Leaf Extract, Rhodiola Rosea (Rhodiola) Root Extract, Aspalathus Linearis (Rooibos) Leaf Extract, Rosa Centifolia (Rose) Flower Extract, Althaea Officinalis (Marshmallow), Stellaria Media (Chickweed), Camellia Sinensis (Gunpowder Green Tea) Leaf Extract, Equisetum Arvense (Horsetail) Leaf Extract, Viola Tricolor (Violet) Extract, Euterpe Oleracea (Acai) Fruit Extract, Emblica Officinalis (Amla) Fruit Extract, Withania Somnifera (Ashwagandha) Root Extract, Boswellia Serrata (Sacred Frankincense) Resin Extract, Silybum Marianum (Milk Thistle) Seed Extract], Aloe Vera Oil [Caprylic/Capric Triglyceride (Fractionated Coconut Oil), Cocos Nucifera (Coconut) Oil, Aloe Barbadensis (Aloe Vera) Leaf Extract], Olea Europaea (Olive) Fruit Oil, Tocopherol (Non-Gmo Vitamin E), Lavandula Angustifolia (Lavender) Oil, Canarium Commune (Elemi) Oil, Myroxylon Balsamum (Peru Balsam) Oil, Boswellia Carterii (Frankincense) Gum Extract
The Glaze Body Oil - DIME Beauty
Product Details
- Quick-drying and non-greasy formula nourishes the skin's barrier, retaining moisture all day.
- Contains a blend of nutrient-rich oils like argan, jojoba, and apricot for deep hydration.
- Can be used as a soothing post-shave oil to calm irritation and redness.
- Sustainable packaging and clean, vegan, cruelty-free ingredients focus on your well-being.
- Safe to use daily with each ingredient having a safe Environmental-Working-Group rating.
Pros & Cons
Pros
- Super hydrating and leaves skin feeling smooth and silky.
- EWG approved for safe, worry-free use.
- Lightweight and non-greasy, perfect for quick absorption.
- Fresh scent that adds a touch of luxury to your skincare.
- Enhances natural skin glow, ideal for a radiant look.
Cons
- Some users noted the scent is grassy, which may not be to everyone's taste.
Ingredients
Ingredients: Helianthus Annuus (Sunflower) Seed Oil, Oryza Sativa (Rice) Bran Oil, Prunus Armeniaca (Apricot) Kernel Oil, Simmondsia Chinensis (Jojoba) Seed Oil, Crambe Abyssinica (Abyssinian) Seed Oil, Prunus Amygdalus Dulcis (Almond) Oil, Limnanthes Alba (Meadowfoam) Seed Oil, Argania Spinosa (Argan) Kernel Oil, Dimethicone, Isosorbide Dicaprylate, Cupressus Sempervirens (Cypress) Oil, Citrus Paradisi (Grapefruit) Peel Oil, Citrus Aurantifolia (Lime) Peel Oil, Rosa Canina (Rosehip) Fruit Oil, Punica Granatum (Pomegranate) Seed Oil, Tocopherol, Dioscorea Villosa (Wild Yam) Root Extract, Uva Ursi (Bearberry) Leaf Extract
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User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Active Body Oil - Boyzz Only
Product Details
- Made with 100% natural ingredients to ensure a safe and clean application.
- CertClean certified for a toxin-free assurance that prioritizes human health.
- Enriched with arnica, eucalyptus, and manuka oil to soothe sore muscles and ease stress.
- Perfect for both professional and home massages, providing a relaxing experience.
- Cruelty-free and vegan, for a guilt-free choice in your skincare routine.
- Nourishes and hydrates the skin, leaving it feeling healthy and rejuvenated.
Pros & Cons
Pros Mentioned
- No Pros
Cons Mentioned
- Broken
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Vitis Vinifera (Grape) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil, Cocos Nucifera (Coconut) Oil, Helianthus Annuus (Sunflower) Seed Oil, Arnica Montana Flower Extract, Ascorbyl Palmitate, Carthamus Tinctorius (Safflower) Seed Oil, Eucalyptus Globulus Leaf Oil, Tocopherol, Leptospermum Scoparium Branch/Leaf Oil
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Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Noni Glow Body Oil - Kora Organics
Product Details
- Deeply hydrates and nourishes skin, leaving it with a healthy, radiant glow.
- Perfect solution for dry skin, smoothing rough texture and enhancing skin tone.
- Infused with Noni Extract, Rosehip Oil, and Sunflower Seed Oil, rich in antioxidants and essential fatty acids.
- Certified organic, cruelty-free, and vegan, without artificial fragrances or colors.
Pros & Cons
Pros
- Enhances the youthful appearance by reducing wrinkles.
- Applies smoothly and improves skin quality without greasiness.
- Pleasantly clean feel with a nice, light fragrance.
- Contains a beneficial blend of natural ingredients.
Cons
- Some users may find the scent slightly unappealing.
- Improved packaging could help prevent damage during shipping.
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Rosa Canina (Rosehip) Seed Oil*, Dicaprylyl Carbonate, Helianthus Annuus (Sunflower) Seed Oil*, Hippophae Rhamnoides (Sea Buckthorn) Seed Oil*, Tocopherol*, Pelargonium Graveolens (Rose Geranium) Flower Oil, Morinda Citrifolia (Noni) Fruit Extract*, Glycine Soja (Soybean) Oil*, Rosa Damascena (Rose) Flower Oil*, Punica Granatum (Pomegranate) Seed Oil*, Citronellol**, Geraniol**, Linalool**, Citral**, Limonene**
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Body Oil - Primally Pure
Product Details
- Delivers lightweight, non-greasy hydration for radiant skin
- Formulated with pure, cold-pressed organic oils
- Blue Tansy calms and heals with anti-inflammatory and antioxidant benefits
- Helps support collagen production and skin regeneration
- Aromatic and nutrient-dense blend absorbs quickly for a smooth finish
Pros & Cons
Pros
- Quickly absorbs and soothes irritation and dryness, leaving skin smooth and healthy.
- Hydrating formula that helps prevent stretch marks, ideal for pregnancy care.
- Luxurious texture and beautiful color enhance the application experience.
- Delightful, long-lasting natural scent that users love.
- Highly praised for consistent use and effectiveness.
Cons
- The scent, while loved by many, may not suit those sensitive to fragrances.
Ingredients
Ingredients: Fractionated Coconut Oil, Sunflower Oil*, Kukui Nut Oil, Sweet Almond Oil*, Argan Oil*, Pomegranate Seed Oil*, Essential Oils of Geranium*, Blue Tansy* and Peppermint*
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Organic Body Oil - Toups & Co
Product Details
- Hydrates and restores skin with a fast-absorbing, non-greasy formula.
- Supports the skin’s microbiome and natural barrier function.
- Made with plant-based oils that mimic your skin’s own moisture.
- Lightly scented with citrus and blue tansy, gentle enough for sensitive skin.
- Free from water, harsh chemicals, and synthetic fragrances.
Pros & Cons
Pros
- Deeply moisturizes skin without leaving a greasy residue.
- Absorbs easily and leaves skin feeling soft, nourished, and refreshed.
- Scents like Vanilla/Almond, Blossom, and Citrus are light, natural, and addictive.
- Great for after-sun care and dry climates, helping reduce peeling and dryness.
- Pairs beautifully with dry brushing for an elevated self-care routine.
Cons
- Scent may fade quickly for those who prefer longer-lasting fragrance.
Ingredients
Ingredients: *Organic Jojoba Oil, *Organic Virgin Olive Oil, Orange Fruit Extract, Sweet Orange Peel Oil, Pink Grapefruit Peel Oil, Organic Bergamot Essential Oil, Anise Fruit Oil, Cognac Oil, Magnolia Essential Oil, Almond Extract, Vanilla Planifolia, Rose Absolute, Jasmine Flower Oil, Blue Tansy Essential Oil
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Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Everybody Loves The Sunshine Body Oil - Living Libations
Product Details
- Organic formula rich in essential oils harmonizes your time in the sun.
- Non-toxic body oil that promotes healthy vitamin D absorption while limiting free radical damage.
- Made from natural, organic, wildcrafted ingredients, handmade in small batches.
- Packaged in recyclable glass and is paraben-free, sulfate-free, cruelty-free, gluten-free, and vegan.
Pros & Cons
Pros
- Offers non-toxic sun protection with natural ingredients.
- Provides a fresh and glowy skin feel.
- A pleasant aroma that users enjoy.
- Absorbs quickly without leaving a greasy residue.
- Can be used by all family members for sun protection.
Cons
- Some users may need time to get accustomed to the product's scent.
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Desert Jojoba Plant, Virgin Coco-Creme, Red Raspberry Seed Oil, Seabuckthorn Berry Oil, Tamanu Berry, Essential Oils Of Schizandra Berry, Immortelle, Carrot Seed, Rose Otto, Cape-Chamomile, Frankincense, Sandalwood, Ginger, Lavender, Turmeric, Calendula, Palmarosa
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Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Mainstay Blend - Everyday Oil
Product Details
- Simplifies skincare routines by serving multiple purposes such as moisturizer, cleanser, and more.
- Made from 100% organic ingredients and certified non-comedogenic.
- Suitable for a variety of skin types, including dry, sensitive, and acne-prone skin.
- Contains essential oils that deliver nutrients and improve skin tone and texture.
- Versatile use as face and body moisturizer, hair oil, and massage oil.
Pros & Cons
Pros
- Versatile oil replaces multiple skincare products for face and body.
- Absorbs quickly and feels hydrating without being greasy.
- Made with high-quality essential oils, offering a refreshing, earthy scent.
- Ideal for everyday use and appreciated by all skin types.
- Soothing scent that’s calming and non-irritating.
Cons
- Some users who are sensitive to fragrances may find the earthy scent unappealing.
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Organic Coconut, Jojoba, Olive, Castor, And Argan Oil, With Mainstay Organic And Wild-Harvested Essential Oils Of Palo Santo, Lavender, Geranium, And Clary Sage
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Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Anti-Aging Jasmine Body Oil - KOA LIFE
Product Details
- Nourishes skin with plant-derived ingredients for a healthy glow.
- Vegan formula uses the power of plants to deeply moisturize.
- Helps even skin tone and reduces the signs of aging.
- Free from sulfates, parabens, and chemicals.
- Cruelty-free for a conscious skincare choice.
Pros & Cons
Pros
- This natural, plant-derived oil leaves skin radiant, toned, and moisturized.
- Contains nourishing ingredients like goji berry, hibiscus flower, and licorice root.
- Quickly absorbs without a greasy residue, making skin feel velvety.
- Ideal for dry skin and doesn't cause breakouts or clogged pores.
- Vegan, cruelty-free, with no mineral oil, sulfates, or parabens.
Cons
- Some users may find the fragrance too strong for facial application.
- Those sensitive to specific oils should note the presence of almond and hemp seed oils.
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Sweet Almond Oil, Grape Seed Oil, Rice Bran Oil, Cannabis Sativa (Hemp) Seed Oil, Jojoba Seed Oil, Olive Fruit Oil, Astragalus Membranous Root Extract, Glycyrrhiza Glabra Root Extract, Shitake Extract
Common Harmful Chemicals in Body Oil
Chemical Name
Why it’s harmful
Linalool is a naturally occurring terpene alcohol found in many flowers and spice plants, consisting of two enantiomers. It is widely used in commercial products for its pleasant floral and spicy scent, serving as a key ingredient in soaps, fragrances, food flavors, household products, and insecticides. In plants, linalool functions as a metabolite, volatile oil component, antimicrobial agent, and aroma compound. Acute exposure to linalool can lead to central depressive effects with symptoms such as ataxia, reduced motor activity, and respiratory disturbances. Additionally, inhalation, oral intake, or skin absorption can result in irritation, pain, and allergic reactions.
d-Limonene is a liquid with a lemon-like smell, often used as a solvent to substitute for more volatile and toxic organic solvents. When it comes into contact with air, it can oxidize, and this oxidized form is a known skin sensitizer, capable of irritating skin and eyes. The combination of d-limonene and l-limonene is known as limonene or dipentene. The estimated lethal dose for humans is between 0.5 to 5 g/kg, and studies have shown that it can cause diarrhea and liver effects when ingested in high doses.
Phthalates, linked to endocrine disruption, reproductive toxicity, and cancer, are banned in the European Union but remain prevalent in U.S. cosmetics. They are widely used in personal care products, such as nail polish, fragrances, and eyelash glue and other products. A significant loophole allows phthalates to be added to fragrances without disclosure. Health concerns include endocrine disruption, developmental and reproductive toxicity, and potential carcinogenicity.
Campaign for Safe Cosmetics: Phthalates, Product Profile: Hand Sanitizer, Phthalates in Cosmetics, Phthalates in cosmetic and personal care products: concentrations and possible dermal exposure, A Survey of Phthalates and Parabens in Personal Care Products from the United States and Its Implications for Human Exposure, Phthalates Factsheet, BPA and Phthalates: Chemicals found in our homes
Butylparaben, a chemical used in various products, has been shown to cause skin irritation in humans and potential sensitization in dermatitis patients. Animal studies indicate that it has low to moderate oral toxicity and can cause damage to the liver, spleen, and thymus. It can also lead to cell proliferation in rats' stomachs, though it was not found to be carcinogenic or mutagenic. However, it may negatively impact sperm viability and activity, as demonstrated in different in vitro and in vivo studies. Lastly, it proposed weaker aquatic toxicity compared to parabens with longer alkyl chains, but still showed estrogenic effects in certain fish species.
Ethylparaben is a chemical used as a preservative in various products including pharmaceuticals, cosmetics, and adhesives. It exhibits low toxicity in humans and animals, but can cause skin irritation, particularly when applied to damaged skin, and may worsen pre-existing skin conditions. Despite causing cell proliferation in rats' forestomachs and chromosomal aberrations in a hamster ovary cell test, it has shown no evidence of causing cancer. However, it was found to be toxic to fetuses at doses toxic to the mother, though it did not cause malformations (nonteratogenic). Interestingly, while it impacted sperm viability in lab conditions, it showed no negative effects on mouse sperm in actuality.
Campaign For Safe Cosmetics: Parabens, Product Profile: Hand Sanitizer, Parabens At A Glance, What to Know About Parabens, The effects of ethylparaben and propylparaben on the development and fecundity of Drosophila melanogaster, Ethylparaben, Amended Safety Assessment of Parabens as Used in Cosmetics, WHAT ARE PARABENS: CHEMICAL FREE LIVING, Biomonitoring Summary
Methylparaben is an antimicrobial preservative used in food, drugs, and cosmetics. Some individuals can develop contact dermatitis on skin exposure, and allergic reactions have been reported on ingestion, though the evidence is not conclusive. Data from animal studies suggest that methylparaben is practically non-toxic and non-irritating in normal skin conditions, with high thresholds for observed adverse effects. However, it showed chromosome aberrations in a cell assay and variable results in different uterotrophic assays. An ecotoxicity study found changes in the expression of certain genes at specific concentrations in male medaka, a type of fish.
Propylparaben is a stable, non-volatile compound utilized as an antimicrobial preservative in food, drugs, and cosmetics. Human exposure can cause sensitization especially if applied to damaged skin and may cause contact sensitivity with high concentrations. Extensive animal studies reveal that propylparaben is relatively non-toxic, yet it can mildly irritate skin, affect sperm counts in substantial levels, and trigger cell proliferation in the forestomach of rats. However, it is not carcinogenic, mutagenic, or clastogenic, and a significant no-observed-adverse-effect level was reported in rats. Ecotoxicity studies show that it can lead to an increase in plasma vitellogenin levels in rainbow trout and a significant decline of vitellogenin production in zebrafish at varying concentrations.
Isobutylparaben belongs to the paraben family of preservatives used in the food, pharmaceutical, and personal care product industries. Parabens mimic estrogen and have been found in breast cancer tumors in some studies. Parabens are commonly found in various personal care products and foods and have been associated with endocrine disruption, skin cancer risk, developmental and reproductive toxicity, and potential behavioral changes in offspring when exposed during gestation.
Isopropylparaben belongs to the parabens family of preservatives utilized in the food, pharmaceutical, and personal care sectors. Parabens have estrogen-mimicking properties and pose a potential risk as endocrine disruptors. Research has detected parabens in the breast cancer tumors of a significant number of studied women, raising concerns about their safety and hormonal effects.
3-tert-Butyl-4-hydroxyanisole is a component of the food preservative Butylated Hydroxyanisole, used where Butylated hydroxytoluene is restricted. It serves as an oxidation inhibitor for human consumption. Despite lacking human studies, animal tests reveal no mutagenic activity. Its mutagenicity was evaluated using Salmonella typhimurium and Chinese hamster fibroblast cell line, with chromosomal aberrations induced only in the presence of the S9 mix.
BHT, a toluene-based ingredient, serves as a preservative in food and personal care products. Safety assessments have noted toxic effects in lung tissue when BHT was applied to rats' skin but considered the low concentrations in cosmetics safe. The American Conference of Governmental Industrial Hygienists (ACGIH) suggests moderate evidence of BHT being a respiratory irritant in humans.
1,4-Dioxane is a clear, water-soluble liquid that is primarily used as a solvent in chemical manufacturing and laboratory reagents. Other uses leverage its solvent properties, including cosmetics, detergents, and shampoos. However, manufacturers generally reduce 1,4-Dioxane to low levels in these products due to its potential health risks. Acute exposure can result in symptoms such as vertigo, drowsiness, and irritation of the eyes, nose, throat, and skin. Chronic exposure may lead to liver and kidney damage, and the substance is classified as a probable human carcinogen by the EPA. Notably, severe kidney and liver damage, CNS effects, and even death have been recorded after heavy or prolonged exposure.
What Is 1,4-Dioxane in Laundry and Cleaning Products?, Effect of ethoxylation and lauryl alcohol on the self-assembly of sodium laurylsulfate: Significant structural and rheological transformation, Final Risk Evaluation for 1,4-Dioxane, Ongoing and Completed Chemical Risk Evaluations under TSCA, Preliminary Information on Manufacturing, Processing, Distribution, Use, and Disposal, TOXICOLOGICAL REVIEW OF 1,4-DIOXANE, 15th Report on Carcinogens, 1,4-Dioxane, Determination of residual 1,4-dioxane in surfactants and cleaning agents using headspace single-drop microextraction followed by gas chromatography–flame ionization detection, 1,4-Dioxane in Cosmetics: A Manufacturing Byproduct, An integrated assessment of the 1,4-dioxane cancer mode of action and threshold response in rodents, Campaign for Safe Cosmetics: 1,4-DIOXANE, Product Profile: Hand Sanitizer, Occurrence of 1,4-dioxane in cosmetic raw materials and finished cosmetic products, Chemical Profile: 1,4-dioxane
Oral administration of high doses in adults causes ciricrhosis, hemorrhage, anorexia, jaundice, and dermatitis. The use of this substance is contraindicated in pregnancy at doses larger than the FDA recommend daily allowance. Ingesting 25,000 IU/d over a period of 2-3 weeks may result in toxicity, symptoms of which include liver injury and increased intracranial pressure, leading to blurred vision, headaches, and changes to mental status. The substance is also found to be an irritant and harmful if ingested, with teratogenic effects observed in experimental animals.
Ethylene oxide is a flammable, sweet-smelling gas that easily dissolves in water. This man-made compound is primarily used to create ethylene glycol, which is used to make antifreeze and polyester, and is also used in small quantities for controlling insects in stored agricultural products, sterilizing medical equipment and fumigating spices. Ethylene oxide may cause irritation of the eyes, skin, nose, throat, and lungs, damage to the brain and nervous system, reproductive effects, and is considered by the EPA to be carcinogenic if inhaled. Exposure risks, which are notably prevalent for healthcare workers engaged in sterilization tasks, include CNS depression, eye and mucous membrane irritation and in some cases, cataracts. Despite these hazards, there are conflicted reports regarding ethylene oxide's carcinogenicity in humans.
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