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Best Non-Toxic Hair Detangler in 2024
Updated:
Nov 18, 2024
Written by Camille May
Cofounder & Product Curator
+ 1 more
Medically reviewed by Olushola Awoyemi
PhD Environmental Toxicology
As an Amazon Associate, we earn from qualifying purchases. Our use of affiliate links does not influence how we rate products. Learn more about our affiliate policy here.
What you should know when choosing non-toxic hair detangler on Welpr:
- Only the cleanest products make it onto Welpr.
- We use a score called the Welpr Rating to rank each product.
- The Welpr Rating is based on math, not opinion, ensuring it's free from human bias.
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Find Non-Toxic Hair Detangler
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Leave-In Hair Detangler - Pipette
Certifications
Highlights
User Satisfaction
Est. Price
$14.90
Product Details
- Effortlessly loosens knots and snarls without leaving residue or stickiness.
- Suitable for all hair types and textures.
- Infused with plant-derived quinoa and panthenol (vitamin B5) to nourish, soften, and detangle hair.
- Contains squalane from renewable sugarcane, adding moisture without weight.
- Formulated without silicones, designed to be gentle on kids' tender scalps.
- Supports hair and scalp health with a hypoallergenic, cruelty-free, and vegan formula.
- Lacks synthetic fragrances; offers a natural orange vanilla aroma.
- EWG Verified to meet strict safety standards.
Pros & Cons
Pros Mentioned
- Detangling
- Softening
- Scent
Cons Mentioned
- Sticky
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Water/Aqua/Eau, Lauryl Glucoside, Sodium Lauroamphoacetate, Glycerin, Citric Acid, Glycolipids, Squalane, Magnesium Chloride, Sodium Benzoate, Sodium Dehydroacetate, Sodium Gluconate
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Natural Sweet Spirit Leave-In Conditioner - Innersense
Certifications
User Satisfaction
Est. Price
$28.00
Product Details
- Lightweight detangling spray that increases moisture and manageability in hair.
- Formulated with natural oils, fragrant herbs, flower essences, and a touch of honey.
- Incorporates ingredients like Tamanu oil, organic rice proteins, and rosemary oil which help in healing, strengthening, and stimulating hair growth.
- Features lavender and rooibos tea known for their healing properties and antioxidants.
- Lavender also acts as an adaptogen, normalizing both dry and oily conditions of the scalp.
- Free from sulfates, parabens, silicones, phthalates, propylene glycol, artificial fragrances, and synthetic dyes.
- Does not contain ethoxylate, PEG, MEA, TEA, MIA, EDTA, and is gluten-free.
- Designed to be cruelty-free with ethically harvested and sourced ingredients from transparent plantations, orchards, and farms around the world.
Pros & Cons
Pros Mentioned
- Moisturizing
- Lightweight
- Natural
Cons Mentioned
- Heavy
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Water/Aqua/Eau, Aloe Barbadensis (Aloe Vera) Leaf Gel*, Cetearyl Alcohol, Glycerin, Distearoylethyl Dimonium Chloride, Caprylic/Capric Triglyceride, Hydrolyzed Quinoa*, Gluconolactone, Sodium Benzoate, Calcium Gluconate, Potassium Sorbate, Benzyl Acetate, Linalyl Acetate, Citronellol†, Abies Balsamea Needle Oil*, Juniperus Virginiana (Cedar) Oil*, Alpha-Terpineol, Amyl Cinnamal†, Linalool†, Pogostemon Cablin (Patchouli) Leaf Oil, Salvia Sclarea (Clary Sage) Oil, Citrus Reticulata (Tangerine) Peel Oil, Mentha Citrata Herb Oil, Eugenia Cayophyllus (Clove) Oil, Michelia Alba Leaf Oil, Lavandula Angustifolia (Lavender) Oil, Citrus Limon (Lemon) Peel Oil, Citrus Aurantifolia (Lime) Oil, Lavandula Hybrida (Lavandin) Oil, Cinnamomum Camphora (Camphor) Bark Oil, Alpha-Ionone, Evernia Prunastri (Oakmoss) Extract, Anisaldehyde, Cistus Ladaniferus Resin, Menthol, Myristica Fragrans (Nutmeg) Kernel Oil, Jasminum Grandiflorum Flower (Jasmine) Extract, Nerol, Benzaldehyde, Chamomilla Recutita (Matricaria) Flower Extract*, Eucalyptus Globulus Leaf Extract*, Ginkgo Biloba Leaf Extract*, Aspalathus Linearis Leaf Extract*, Honey Extract*, Calophyllum Inophyllum (Tamanu) Oil, Rosmarinus Officinalis (Rosemary) Oil, Citric Acid, Eugenol†, Limonene† *Certified Organic, †A Natural Component Of Essential Oils
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Hydration Detangler + UV Barrier - Rahua
Highlights
User Satisfaction
Est. Price
$34.00
Product Details
- Moisturizing formula softens hair
- Smooths frizz
- Prevents breakage and damage
- Creates instantly brushable hair
- Best for all hair types
Pros & Cons
Pros Mentioned
- Detangling
- Hydrating
- Natural
Cons Mentioned
- Heavy
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Aqua, Herbal Infusion Of Organic Mangifera Indica (Mango) Fruit Extract, Organic Passiflora Incarnate (Passion) Fruit Extract, Organic Aloe Barbadensis Leaf Extract And Organic Camellia Sinensis (Green Tea) Leaf Extract, Behentrimonium Methosulfate, Oenocarpus Bataua (Rahua, Ungurahua) Oil, Mauritia Flexuosa (Morete) Fruit Oil, Vegetable Glycerin, Plukenetia Volubilis (Sacha Inchi) Seed Oil, Citric Acid, Kaolin Clay, Cymbopogon Nardus (Citronella) Oil, Saccharum Officinarum (Sugar Cane), Propanediol, Polyglyceryl 4 Oleate, Potassium Sorbate, Natural Aroma, Guar Gum, Behentrimonium Chloride, Helianthus Annuus (Sunflower) Seed Oil
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Kids Detangler Hair Spray and Toddler Leave In Conditioner - Totlogic
Certifications
Highlights
User Satisfaction
Est. Price
$16.95
Product Details
- Formulated for all hair types, effective in easing combing for wavy, curly, coily, and frizzy hair.
- Rich in antioxidants and nourishing botanicals to detangle, condition, combat frizz, and prevent split ends.
- Usable on wet or dry hair.
- Naturally scented with Bergamot, Chamomile, and Lavender essential oils, free from artificial dyes or colorants.
- Free from harsh chemicals such as sulfates, formaldehyde, phthalates, parabens, SLS, SLES, MEA, DEA, TEA, petroleum-derived ingredients, methylisothiazolinone, and MI.
- Lightly scented with a blend of chamomile and bergamot, carrying both floral and citrus notes.
- Safe, gentle, cruelty-free, and vegan, suitable for use by the entire family including pets.
- Manufactured in the USA using plant-based ingredients.
- Free from synthetic dyes, fragrances, and other harmful chemicals.
Pros & Cons
Pros Mentioned
- Moisturizing
- Lightweight
- Non-toxic
Cons Mentioned
- Smell
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Purified Water, Panthenol (Vitiamin B5), Amodimethicone, Simmondsia Chinensis (Jojoba Oil), Polysorbate-20, Phenoxyethanol, Ethyl Hexyl Glycerin, Lavandula Angustifolia (Lavender) Essential Oil, Citrus Bergamia (Bergamot) Essential Oil, Mentha Avensis (Wild Mint) Essential Oil, Medica Limonum (Lemon Peel) Oil, Ocimum Basillcum (Basil) Essential Oil
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
7SECONDS Detangler Leave-In Conditioner - Unite
Certifications
Highlights
User Satisfaction
Est. Price
$38.00
Pros & Cons
Pros Mentioned
- Silky
- Moisturizing
- Detangling
Cons Mentioned
- Expensive
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Water/Aqua/Eau, Sd Alcohol 40-B/Alcohol Denat., Cetearyl Alcohol, Amodimethicone, Cetrimonium Chloride, Cyclotetrasiloxane, Hydrolyzed Rice Protein, Panthenol, Trideceth-12, Behentrimonium Methosulfate, Fragrance/Parfum, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Hydroxyacetophenone, Sodium Benzoate, Benzyl Benzoate, Benzyl Salicylate, Citral, Geraniol, Limonene, Linalool, Amyl Cinnamal, Hexyl Cinnamal, Hydroxycitronellal, Butylphenyl Methylpropional, Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Coconut Milk Detangle Elixir - Pacifica
Certifications
Highlights
User Satisfaction
Est. Price
$9.99
Product Details
- Hydrating detangling spray that minimizes comb-through breakage.
- Provides leave-on conditioning without weighing down hair.
- Imparts a fresh coconut scent.
- Usage: Spray on clean, wet hair before combing; do not rinse out; can be used daily.
- Formulated with coconut and vitamin B.
- Free of parabens, phthalates, SLS, mineral oil, petrolatum, silicone, and sulfates.
- 100% vegan and cruelty-free.
Pros & Cons
Pros Mentioned
- Moisturizing
- Detangling
- Lightweight
Cons Mentioned
- Drying
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Aqua, Glycerin, Cetyl Alcohol, Parfum, Behentrimonium Chloride, Glyceryl Stearate, Aloe Barbadensis Leaf Juice, Panthenol (Vitamin B5), Hydrolyzed Soy Protein, Hydrolyzed Barley Protein, Simmondsia Chinensis (Jojoba) Seed Oil, Cocos Nucifera (Coconut) Water, Butyrospermum Parkii (Shea) Butter, Sodium Benzoate, Ethylhexylglycerin
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Conditioning Hair Detangler - The Honest Company
Certifications
Highlights
User Satisfaction
Est. Price
$6.59
Product Details
- Leave-in lightweight conditioner that detangles knots and enhances manageability, leaving hair soft, smooth, and moisturized.
- Suitable for all hair types and can be used by the entire family.
- Formulated without parabens, dyes, synthetic fragrances, silicones, sulfates, or formaldehyde donors.
- Features a blend of naturally-derived ingredients including argan oil, jojoba protein, shea butter, and quinoa extracts to soften and smooth hair.
- Tear-free, hypoallergenic, and dermatologist-tested.
- Produced in the USA, cruelty-free, and does not contain animal byproducts.
Pros & Cons
Pros Mentioned
- Detangling
- Lightweight
- Hydrating
Cons Mentioned
- Weighty
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Water, Glycerin, Behentrimonium Chloride, Calendula Officinalis (Calendula) Flower Extract*, Chamomilla Recutita (Matricaria) Flower Extract*, Vanilla Planifolia (Vanilla) Fruit Extract, Cocos Nucifera (Coconut) Oil*, Crambe Abyssinica Seed Oil, Orbignya Speciosa Kernel Oil, Citrus Tangerina (Tangerine) Peel Oil, Argania Spinosa (Argan) Kernel Oil*, Citrus Aurantium Dulcis (Orange) Peel Oil, Astrocaryum Murumuru Seed Butter, Butyrospermum Parkii (Shea) Butter*, Hydrolyzed Jojoba Protein, Hydrolyzed Quinoa, Caprylhydroxamic Acid, Panthenol, Triethyl Citrate, Caprylyl Glycol
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Shea Butter Deep Moisturizing Detangler - SheaMoisture
Certifications
Highlights
User Satisfaction
Est. Price
$9.89
Product Details
- Formulated with Fair Trade Shea Butter to soften, condition, and renew damaged, transitioning, or frizzy hair.
- Offers a lightweight formula that provides perfect slip to help release knots and tangles, minimizing hair breakage.
- Can be used pre- or post-wash to facilitate easier detangling.
- Enriched with Raw Shea Butter, Sea Kelp, and Argan Oil to infuse hair with moisture and essential nutrients.
- Delivers 9x more moisture compared to non-conditioning shampoo, enhancing hair's hydration levels.
- Compatible with other SheaMoisture products for a comprehensive hair care routine.
- Formulated for both detangling and frizz control, serving as an effective leave-in styling product.
- Cruelty-free and sustainably produced with natural ingredients.
- Supports the company's legacy of reinvestment in community initiatives and maintaining traditional craftsmanship.
Pros & Cons
Pros Mentioned
- Softening
- Effective
- Moisturizing
Cons Mentioned
- Smelly
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Water (Eau), Glycerin (Vegetable/Végétale), Cetearyl Alcohol, Butyrospermum Parkii (Shea) Butter, Stearamidopropyl Dimethylamine, Capryloyl Glycerin/Sebacic Acid Copolymer, Behentrimonium Chloride, Argania Spinosa (Argan) Kernel Oil, Macrocystis Pyrifera (Kelp) Extract, Panthenol, Polyquaternium-7, Diheptyl Succinate, Sodium Chloride, Citric Acid, Sodium Benzoate, Triethyl Citrate, Caprylyl Glycol, Benzoic Acid, Fragrance (Parfum)
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
OI All in One Milk - Davines
Certifications
Highlights
User Satisfaction
Est. Price
$40.00
Product Details
- Acts as a powerful hair detangler.
- Provides heat protection.
- Helps smooth frizzy hair.
Pros & Cons
Pros Mentioned
- Moisturizing
- Detangling
- Softening
Cons Mentioned
- Pricey
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Water, Cetearyl Alcohol, Fragrance, Behentrimonium Chloride, Benzyl Alcohol, Tocopherol, Cetyl Alcohol, Amodimethicone, Cetrimonium Chloride, Amodimethicone, Silsesquioxane Copolymer, Sodium Benzoate, Trideceth-5, Citric Acid, Glycerin, Trideceth-12, Cyclopentasiloxane, Citronellol, Geraniol, Phenoxyethanol, Helianthus Annus, Sunflower, Seed Oil, Linalool, Alpha-Isomethyl Ionone, Limonene, Bixa Orellana Seed Extract
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all personal care and cosmetic products on Welpr.
Be Gentle Be Kind Aloe + Oat Milk Ultra Soothing Detangling Spray - Briogeo
Certifications
Highlights
User Satisfaction
Est. Price
$25.00
Product Details
- Formulated for individuals sensitive to fragrance, essential oils, lactose, soy, and gluten; suitable for all hair types including straight, wavy, curly, and coily.
- Hypoallergenic, fragrance and essential oil-free leave-in detangler, dermatologist-approved.
- Contains aloe vera, oat extract, and natural oils to calm, nourish, and hydrate hair, leaving it shiny with a lightweight finish.
- 99% naturally-derived, vegan, and cruelty-free.
- Packaging is eco-friendly, 100% recyclable, and made from 100% post-consumer resin.
- To use: Spray on clean, damp hair focusing on mid-length to ends before air or blow-drying. Do not rinse out.
- For optimal results, use after cleansing and conditioning with Be Gentle, Be Kind ultra soothing shampoo and conditioner.
Pros & Cons
Pros Mentioned
- Moisturizing
- Softening
- Detangling
Cons Mentioned
- Smelly
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use INCIDecoder.
Ingredients: Water/Aqua/Eau, Polyglyceryl-6 Stearate, Isopropyl Palmitate, Vitis Vinifera (Grape) Seed Oil, Glycerin, Limnanthes Alba (Meadowfoam) Seed Oil, Aloe Barbadensis Leaf Juice, Avena Sativa (Oat) Bran Extract, Camellia Sinensis Leaf Extract, Simmondsia Chinensis (Jojoba) Seed Oil, Cetrimonium Chloride, Cetearyl Alcohol, Panthenol, Leuconostoc/Radish Root Ferment Filtrate, Glyceryl Stearate, Polyglyceryl-6 Behenate, Tocopheryl Acetate, Citric Acid, Potassium Sorbate, Sodium Benzoate, Caprylhydroxamic Acid, Benzyl Alcohol
Our Product Rating System
First, Camille (co-creator of Welpr) hand picks cleaner product options from a variety of sources.
Next, we collect information about each product's safety, consumer satisfaction, and eco-ethical standing.
Finally, we run all this information through an algorithm that calculates the Welpr Rating.
Welpr Rating:
5.0/5
Part 1: Product safety
We evaluate safety information from 3rd party organizations (e.g. EWG, Made Safe, etc.). Instead of relying solely on any one of these companies for safety information, we assess all of them.
Part 2: Consumer satisfaction
We scour the web for consumer ratings and reviews to verify products are not only cleaner options, but also effective. Products can either be Above Average, Average, or Below average for their respective category (e.g. cleaning products).
Part 3: Ethics & Environment
When you buy a product, you’re supporting that company with your dollars. We believe it’s important to support ethical companies, so we pool together certifications that verify a company's ethics and environmental impact.
Common Harmful Chemicals in Hair Detangler
Chemical Name
Why it’s harmful
Cetrimonium Bromide
Cetrimonium Bromide is a versatile substance utilized in various products, including topical anti-bacterial and anti-fungal preparations, cosmetics, hair care, throat lozenges, antiseptic gels, and vaccine production. It serves as a surfactant and emulsifier and typically requires skin contact to cause a rash. Its applications range from skincare and haircare products to throat lozenges and vaccine production.
Polyquaternium
Polyquaternium, modified polymers through quaternization are known for skin toxicity and allergenicity. Prolonged exposure, especially for hairdressers and janitors, may pose risks. It's found in various products, including hair conditioners, creams, and household cleaning items. Concerns include skin irritation, formaldehyde release, and contact dermatitis. Regulations in the EU limit Quaternium-15 to 0.2% in cosmetics, while the US lacks specific regulations.
Sodium Laureth Sulfate
Sodium laureth sulfate, derived from ethoxylated lauryl alcohol, is a surfactant used in sudsy products like toothpaste, detergents, and shampoos. While it acts as a cleansing and emulsifying agent, it can sometimes contain toxic impurities such as 1,4-dioxane. This chemical has raised health concerns due to its potential to cause skin, lung, and eye irritation, organ toxicity, and, primarily because of contamination by 1,4 dioxane, cancer.
Sources:
The Dirty Dozen: Sodium Laureth Sulfate, 15 Toxic Trespassers, SKIP PRODUCTS MADE WITH SLES (AND SLS, TOO!), Campaign for Safe Costmetics: 1,4-DIOXANE, WHAT IS SODIUM LAURETH SULFATE: CHEMICAL FREE LIVING, A new formula for a mild body cleanser: sodium laureth sulphate supplemented with sodium laureth carboxylate and lauryl glucoside,
Sodium Lauryl Sulfate
Sodium Lauryl Sulfate is recognised as a skin, eye, and respiratory tract irritant according to ICSC. It may cause allergic reactions and eye irritation as stated by the HSDB. Exposure may even result in eye burns, as per CAMEO. Depending on its form - which may range from a solid (90-98% purity), to a paste (30-41%), or an aqueous solution (28-50%) - it can significantly irritate skin and eyes, with adverse effects escalating with increased concentration. Despite these hazards, it is not a skin sensitizer according to CHEMINFO, while eChemPortal: ERMA and MSDSonline endorse its classification as an irritant.
DMDM hydantoin
DMDM hydantoin is a substance used in cosmetics that has the potential to cause allergic contact dermatitis, although rinse-off products generally have a low risk. According to various reports, skin sensitization patch testing has yielded positive results.
Formaldehyde
Formaldehyde is a colorless, flammable gas with a pungent smell that's naturally produced in small quantities in human bodies and is also known as methanal amongst other names. It's used in the production of various items such as fertilizers, paper, plywood, and urea-formaldehyde resins as well as in some foods and household products like antiseptics, medicines, and cosmetics. Exposure to formaldehyde, which can occur through breathing contaminated indoor air, tobacco smoke, or ambient urban air can lead to respiratory symptoms, irritation of the eyes, nose and throat and has been linked to lung and nasopharyngeal cancer as well as leukemia. The EPA considers formaldehyde a probable human carcinogen (Group B1) and inhaling it can cause bronchospasm and pulmonary edema. Commercially, it's sold as formalin in solutions of 37%, 44%, or 50% and long-term exposure can cause first-degree burns, skin sensitization, squamous cell nasal cancer, and chronic pulmonary obstruction.
Sources:
Formaldehyde and Cancer Risk, Cleaning Products & Indoor Air Quality, No More Toxic Tub, Campaign for Safe Cosmetics: Preservatives, Campaign for Safe Cosmetics: Formaldehyde And Formaldehyde-Releasing Preservatives, Formaldehyde may be found in cosmetic products even when unlabelled, Formaldehyde Found in Popular American Beauty Products, Hair Salons - Formaldehyde in Your Products, Formaldehyde in cosmetic products
Butylparaben
Butylparaben, a chemical used in various products, has been shown to cause skin irritation in humans and potential sensitization in dermatitis patients. Animal studies indicate that it has low to moderate oral toxicity and can cause damage to the liver, spleen, and thymus. It can also lead to cell proliferation in rats' stomachs, though it was not found to be carcinogenic or mutagenic. However, it may negatively impact sperm viability and activity, as demonstrated in different in vitro and in vivo studies. Lastly, it proposed weaker aquatic toxicity compared to parabens with longer alkyl chains, but still showed estrogenic effects in certain fish species.
Ethylparaben
Ethylparaben is a chemical used as a preservative in various products including pharmaceuticals, cosmetics, and adhesives. It exhibits low toxicity in humans and animals, but can cause skin irritation, particularly when applied to damaged skin, and may worsen pre-existing skin conditions. Despite causing cell proliferation in rats' forestomachs and chromosomal aberrations in a hamster ovary cell test, it has shown no evidence of causing cancer. However, it was found to be toxic to fetuses at doses toxic to the mother, though it did not cause malformations (nonteratogenic). Interestingly, while it impacted sperm viability in lab conditions, it showed no negative effects on mouse sperm in actuality.
Sources:
Campaign For Safe Cosmetics: Parabens, Product Profile: Hand Sanitizer, Parabens At A Glance, What to Know About Parabens, The effects of ethylparaben and propylparaben on the development and fecundity of Drosophila melanogaster, Ethylparaben, Amended Safety Assessment of Parabens as Used in Cosmetics, WHAT ARE PARABENS: CHEMICAL FREE LIVING, Biomonitoring Summary
Methylparaben
Methylparaben is an antimicrobial preservative used in food, drugs, and cosmetics. Some individuals can develop contact dermatitis on skin exposure, and allergic reactions have been reported on ingestion, though the evidence is not conclusive. Data from animal studies suggest that methylparaben is practically non-toxic and non-irritating in normal skin conditions, with high thresholds for observed adverse effects. However, it showed chromosome aberrations in a cell assay and variable results in different uterotrophic assays. An ecotoxicity study found changes in the expression of certain genes at specific concentrations in male medaka, a type of fish.
Propylparaben
Propylparaben is a stable, non-volatile compound utilized as an antimicrobial preservative in food, drugs, and cosmetics. Human exposure can cause sensitization especially if applied to damaged skin and may cause contact sensitivity with high concentrations. Extensive animal studies reveal that propylparaben is relatively non-toxic, yet it can mildly irritate skin, affect sperm counts in substantial levels, and trigger cell proliferation in the forestomach of rats. However, it is not carcinogenic, mutagenic, or clastogenic, and a significant no-observed-adverse-effect level was reported in rats. Ecotoxicity studies show that it can lead to an increase in plasma vitellogenin levels in rainbow trout and a significant decline of vitellogenin production in zebrafish at varying concentrations.
Isobutylparaben
Isobutylparaben belongs to the paraben family of preservatives used in the food, pharmaceutical, and personal care product industries. Parabens mimic estrogen and have been found in breast cancer tumors in some studies. Parabens are commonly found in various personal care products and foods and have been associated with endocrine disruption, skin cancer risk, developmental and reproductive toxicity, and potential behavioral changes in offspring when exposed during gestation.
Isopropylparaben
Isopropylparaben belongs to the parabens family of preservatives utilized in the food, pharmaceutical, and personal care sectors. Parabens have estrogen-mimicking properties and pose a potential risk as endocrine disruptors. Research has detected parabens in the breast cancer tumors of a significant number of studied women, raising concerns about their safety and hormonal effects.
Isopropyl Alcohol
Isopropyl alcohol has been shown to cause narcosis in animals during acute studies, as cited by ACGIH. However, according to research by Zimmerman, it is not hepatotoxic in either experimental animal studies or in human exposures. It's known to be a skin, eye, and respiratory tract irritant, and if inhaled in high concentrations, it can cause CNS depression, as indicated by the ICSC.
Triclosan
Triclosan is a synthetic pesticide with antibacterial properties commonly added to detergents, soaps, and various personal care products such as deodorants and toothpastes. Although it lacks the ability to combat viruses causing colds and flus, it's used in products like body washes, disinfectants, and some toothpastes to resist bacterial growth. In 2016, the FDA limited its use in antibacterial soaps, but the compound is still permitted in other products. The European Union prohibited its presence in food-contact items in 2010. Exposure to triclosan has been associated with hormone disruption, increased breast cancer risk, liver damage, and the development of resistant super-germs.
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Triclosan Exposure, Transformation, and Human Health Effects, Are antibacterial products with triclosan fueling bacterial resistance?, Antimicrobial agents, triclosan, chloroxylenol, methylisothiazolinone and borax, used in cleaning had genotoxic and histopathologic effects on rainbow trout, The Effects of Triclosan on Puberty and Thyroid Hormones in Male Wistar Rats, Triclosan is a potent inhibitor of estradiol and estrone sulfonation in sheep placenta, The in Vitro estrogenic activities of triclosan and triclocarban, Antibacterial Soap? You Can Skip It, Use Plain Soap and Water, Environmental Exposure of Aquatic and Terrestrial Biota to Triclosan and Triclocarban, Triclosan: Environmental Fate and Effects, Chemical Profile: Triclosan / Triclocarban, 5 Things to Know About Triclosan, Underarm Harm? Whats So Bad About Antiperspirants?, Some flame retardants and the antimicrobials triclosan and triclocarban enhance the androgenic activity in vitro, Triclocarban Enhances Testosterone Action: A New Type of Endocrine Disruptor?, Triclosan, a commonly used bactericide found in human milk and in the aquatic environment in Sweden
Ethanolamine
Ethanolamine is a liquid that can cause first-degree burns on short exposure. It is known to be a skin irritant and can cause allergic contact dermatitis. Occupational exposure, notably among hairdressers, has been linked to asthma. Inhalation of ethanolamine in high concentrations can lead to Central Nervous System (CNS) depression and can be toxic to the liver, as shown in subchronic inhalation studies in animals. It is also a skin, eye, and respiratory tract irritant, with the potential to sensitize the skin.
Monoethanolamine
2-Aminoethanol is a colorless, viscous liquid that, despite not being registered for pesticide use in the U.S, holds vast potential in a variety of applications. It can be used in cutting fluids, production of soaps, surfactants, salts, corrosion control inhibitors, pharmaceuticals, and even in protective topical solutions against chemical warfare agents. Used as a pharmaceutical adjuvant, 2-Aminoethanol is effective as a solvent for fats and oils and in creating emulsion formulas like lotions and creams. However, it poses health risks, as a 5.9% concentration can irritate human skin and inhalation may cause allergic reactions, liver damage, and liver symptoms.
Diethanolamine
Diethanolamine is a chemical found in various consumer products like shampoos, cosmetics, and pharmaceuticals. Acute exposure in humans can result in irritation of the nose, throat, and skin. However, no detailed data is available on its chronic, reproductive, developmental or carcinogenic effects on humans. Studies on animals reveal that acute oral exposure can influence the liver, blood, kidney, and central nervous system, while dermal exposure has been connected with an increased incidence of liver and kidney tumors in mice. Production of first-degree burns, skin irritation, occupational asthma, kidney, and liver injury risk, and potential skin sensitization are some other adverse effects associated with diethanolamine.
Sources:
Chemical Safety Facts: Ethanolamines, NTP Toxicology and Carcinogenesis Studies of Diethanolamine, California Environmental Protection Agency: Diethanolamine , International Agency for Research on Cancer: Diethanolamine, Initial List of Hazardous Air Pollutants with Modifications, What is the Toxics Release Inventory?, OPINION CONCERNING DIALKYL- AND DIALKANOLAMINES AND THEIR SALTS IN COSMETIC PRODUCTS, Ethanolamine Compounds (MEA, DEA, TEA And Others), WHAT ARE ETHANOLAMINE COMPOUNDS (DEA, MEA, OR TEA): CHEMICAL FREE LIVING, The Dirty Dozen: DEA-related ingredients, FDA: Diethanolamine, Chemical Profile: Diethanolamine ,
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