Best Non-Toxic Degreaser in 2024
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What you should know when choosing non-toxic degreasers on Welpr:
- Only the cleanest products make it onto Welpr.
- We use a score called the Welpr Rating to rank each product.
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Sal Suds Biodegradable Cleaner, Pine - Dr. Bronner's
Product Details
- Versatile all-purpose cleaner suitable for cleaning floors, laundry, dishes, furniture, and cars, without irritating skin.
- Effective in both hard and soft water, rinses freely in hot or cold water and rapidly biodegrades.
- Formulated with plant-based surfactants that cut grease and dirt, producing copious suds.
- Mildly scented with pure fir and spruce essential oils, free from synthetic dyes, fragrances, or preservatives, phthalates, and ammonium compounds.
- Product ingredients are never tested on animals and bear the Leaping Bunny logo for cruelty-free certification.
- Contains the purest organic and fair trade ingredients, promoting regenerative organic farming practices to enrich soil and increase biodiversity.
- Certifications include USDA Certified Organic, Fair For Life, Certified Vegan, Certified Leaping Bunny, and B Corp, ensuring ethical standards and environmental responsibility.
- Supports various causes like regenerative agriculture, fair trade, wage equality, and animal welfare.
- Emphasizes sustainability with a commitment to using renewable energy and post-consumer recycled plastic in product packaging.
Pros & Cons
Pros Mentioned
- Versatile
- Concentrated
- Effective
Cons Mentioned
- Pricey
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use this EWG tool.
Ingredients: Water, Sodium Lauryl Sulfate, Coco-Betaine, Decyl Glucoside, Abies Siberica (Siberian Fir) Needle Oil, Picea Glauca (Spruce) Leaf Oil, Citric Acid, Sodium Sulfate, Sodium Chloride, Potassium Hydroxide
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Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all cleaning products on Welpr.
Natural Multi-Surface Cleaner, Green Tea & Lime - Puracy
Product Details
- Recognized as "The Best All-Purpose Cleaner" by The New York Times
- Effectively formulated to clean any hard surface without causing streaks
- Developed and tested by PhDs, this plant-based formula addresses a wide range of household stains and residues including food, soda, grease, and more
- Usable on multiple surfaces such as kitchen countertops, electronics, hardwood floors, jewelry, and various metals and stones
- Designed to reduce plastic usage by 90% and comes concentrated enough to create one gallon of cleaner
- Safe for children, pets, and all household surfaces; hypoallergenic, vegan, and gluten-free
- Ensures sparkling, residue-free results on diverse surfaces
- Biodegradable and cruelty-free, never tested on animals
- Produced in the USA
- Infused with a scent of freshly steeped green tea leaves and lime with a touch of herbs
Pros & Cons
Pros Mentioned
- Efficient
- Natural
- Versatile
Cons Mentioned
- Sticky
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use this EWG tool.
Ingredients: Purified Water, Decyl Glucoside (Sugar-Based Cleanser), C6-C12 Alcohol Ethoxylate (Sugar-Based Cleanser), C12-C15 Alcohol Ethoxylate (Plant-Based Cleanser), C9-C11 Alcohol Ethoxylate (Plant-Based Cleanser), Citric Acid (Plant-Based pH Neutralizer), Sodium Citrate (Plant-Based pH Neutralizer), Natural Green Tea & Lime Botanical Extracts, Benzisothiazolinone (Biodegradable Preservative)
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User satisfaction is calculated using online reviews and a Bayesian average across all cleaning products on Welpr.
Powder Cleanser for Kitchens & Bathrooms, Unscented - Bon Ami
Product Details
- Hypoallergenic and non-toxic formula
- Free from chlorine, perfumes, and dyes
- Cleans without scratching surfaces
- Effective on various surfaces including kitchens and bathrooms
- Polishes surfaces and absorbs odors
- Biodegradable composition
- Ingredients are simple and listed on the package
Pros & Cons
Pros Mentioned
- Effective
- Non-abrasive
- Gentle
Cons Mentioned
- Expensive
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use this EWG tool.
Ingredients: Calcium Carbonate (Limestone), Feldspar Powder, Sodium Carbonate (Soda Ash), Sodium Bicarbonate (Baking Soda), C10-C16 Alkylbenzene Sulfonic Acid (Surfactant)
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all cleaning products on Welpr.
All-Purpose Cleaner, Unscented - SuperGreen
Product Details
- Scent free for powerful cleaning without the residual unpleasant odors.
- Multi-surface use enabled, suitable for kitchens, bathrooms, garages, dining rooms, and various flooring types.
- Made from plant-based ingredients, eliminating harsh chemicals.
- Streak-free formula ensures cleanliness without redoing efforts.
- Doubles as a degreaser, effectively cleaning saucepans, barbecues, ovens, and additional greasy surfaces.
- Safe for use on all types of surfaces, ensuring versatility.
- Designed to perform comparably or better than leading brands.
- Leaves no streaks or residues to maintain surface integrity.
- Septic safe, highlighting eco-friendly disposal traits.
Pros & Cons
Pros Mentioned
- Effective
- Natural
- Safe
Cons Mentioned
- Ineffective
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use this EWG tool.
Ingredients: Trade Secret, Ethoxylated Lauryl Alcohol, Sodium Citrate, Water
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all cleaning products on Welpr.
Oven Scrub Cleaner, Unscented - Everneat
Product Details
- Utilizes plant-based ingredients for a deep, chemical-free clean, making it safe and effective.
- Designed for both traditional and self-cleaning ovens to effectively remove stubborn grease and grime.
- Biodegradable, non-toxic formulation that is gentle on hands and environmentally friendly.
- Features refillable concentrates to help reduce packaging waste and clutter.
- Safe for use around children and pets, available in both scented and unscented options to accommodate allergies.
- Includes a jar of Oven Scrub, a bottle of Surface Cleaner, and a commercial-grade Steel Scrubber for comprehensive cleaning.
- Endorsed by media outlets like Buzzfeed, HuffPost, and Real Simple for its all-natural, effective cleaning properties.
Pros & Cons
Pros Mentioned
- Effective
- Non-toxic
- Fast
Cons Mentioned
- Pricey
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use this EWG tool.
Ingredients: Sodium Bicarbonate, Pumice Stone, Sodium Carbonate, Calcium Carbonate, Water, Isopropylidene Glycerol (Glycerine Derived), Alkyl Polyglucoside, Sodium Citrate, Citric Acid, Glycerine, Xantham Gum, Essential Oils (Based On Your Selected Blend)
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Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all cleaning products on Welpr.
Pro Degreaser, Unscented - Morton
Product Details
- Highly effective at breaking down grease and leaving surfaces clean and bright.
- Safe to use around food, including on dishes, pots, pans, countertops, and appliances.
- Ideal for cleaning hard, nonporous surfaces.
- Ready to use immediately upon arrival without requiring any mixing.
- Nontoxic and nonirritating formula free from alcohol, ammonia, bleach, quats, VOCs, and does not leave toxic residues.
- Contains no fragrances, dyes, or aerosols.
- Manufactured and distributed in the USA.
- Formulated with Sodium hydroxide (NaOH), derived from simple materials like salt and water and effective through a process of chlorination.
- Sodium hydroxide is produced using salt water and electricity, and is adjusted in concentration for various applications.
Pros & Cons
Pros Mentioned
- Effective
- Natural
- Safe
Cons Mentioned
- Ineffective
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use this EWG tool.
Ingredients: Sodium Hydroxide, Water
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all cleaning products on Welpr.
Kitchen Power Degreaser, Fragrance Free - Grab Green
Product Details
- Eco-friendly formula is biodegradable and free from solvents or noxious odors.
- Effectively removes kitchen grease and grime, leaving surfaces streak-free and residue-free.
- Features a soothing thyme with fig leaf scent derived from thyme and sage essential oils.
- Naturally-derived plant and mineral-based ingredients are septic safe and provide reliable cleaning power.
- Proudly cruelty-free, never tested on animals, and made in the USA.
- Adheres to full ingredient disclosure, listing every ingredient along with its purpose on each package (True Transparency).
- Owned and operated by women and mothers, emphasizing the use of non-toxic and naturally-derived ingredients.
Pros & Cons
Pros Mentioned
- Effective
- Non-toxic
- Pleasant
Cons Mentioned
- Inconsistent
Ingredients
Ingredients can vary by product variation and may change at any time by the manufacturer. For the most complete and up-to-date list of ingredients, refer to the product packaging.
To analyze individual ingredients, use this EWG tool.
Ingredients: Deionized Water, Sodium Sesquicarbonate, Sodium Laurylglucosides Hydroxypropylsulfonate, Sodium Citrate, Lauramine Oxide, Magnesium Nitrate, Methylchloroisothiazolinone, Magnesium Chloride, Methylisothiazolinone
Third-party certifications are key indicators of a product's safety, ethics, and environmental impact. Click the icon to verify the certification.
Highlights aren't always verifiable, so you're trusting the brand when they say "lead free", etc. If the highlight icon is "clickable", it means we've verified the highlight.
User satisfaction is calculated using online reviews and a Bayesian average across all cleaning products on Welpr.
Multi Purpose Stain Remover Concentrate, Fresh - Alevai
Product Details
- Eco-friendly and made from natural, biodegradable ingredients that are safe for the environment.
- Non-toxic and safe for use around children and pets.
- Effective at removing tough stains such as coffee, wine, grease, pet stains, and grass with over 500 uses.
- Versatile, suitable for a wide variety of surfaces and fabrics including carpets, upholstery, clothing, and more.
- Plant-based formula eliminates the need for multiple cleaning products, offering convenience and cost-effectiveness.
- Cruelty-free, gluten-free, vegan certified, and SLS-Free.
Pros & Cons
Pros Mentioned
- Effective
- Versatile
- Eco-friendly
Cons Mentioned
- Strong
Common Harmful Chemicals in Degreaser
Chemical Name
Why it’s harmful
1-Bromopropane is a colorless liquid that is commercially used with additives to boost its performance in applications and prevent decomposition. Initially, it was utilized in the production of pesticides, fragrances, pharmaceuticals, and other chemicals. However, studies have shown that exposure to 1-bromopropane can lead to various health issues including reddening of the skin, peripheral neuropathy, reproductive toxicity, hepatotoxicity, and neurotoxicity. It has been found that adverse effects occur in animals exposed to levels above 250 ppm and 200 ppm. Furthermore, workers in factories that produce 1-Bromopropane have exhibited signs of toxicity affecting the central nervous system and peripheral nerves.
Trichloroethylene (TCE) is a colorless, nonflammable liquid primarily used as an industrial solvent, featuring in products like adhesives, paint removers, and correction fluids. It's not natural to the environment but has been found in groundwater and surface waters due to its manufacture and disposal. Exposure to TCE, either short-term or chronic, can impact the central nervous system and cause symptoms such as dizziness, confusion and weakness, while also affecting other organs like the liver and kidneys. It has even been linked to several types of cancer, particularly in the kidneys, liver, cervix and lymphatic system. Although TCE itself poses a low fire hazard, under certain conditions like exposure to flames or other specific metals, it can produce phosgene, a highly toxic gas, or react violently with other strong oxidizers. To handle or transport TCE safely, it should be stored in steel drums in a cool, dry, well-ventilated area.
Tetrachloroethylene is a manufactured chemical primarily used for dry cleaning and metal-degreasing, and also serves as an ingredient in other chemicals and consumer products. It can cause central nervous system depression, liver and kidney damage, and induce anesthesia when inhaled in high concentrations. Tetrachloroethylene is also associated with causing skeletal abnormalities in mice and increased spontaneous abortion rates in women exposed to it occupationally in Finland. Despite its potential harmful effects, a study found no clear link between occupational exposure and subsequent cancer incidence. Remedial measures like ventilating affected areas and donning protective clothing are recommended for handling spills; its containers should be kept away from fire to prevent production of poisonous phosgene gas.
The perchloroethylene-induced toxicity in dry cleaning workers lymphocytes through induction of oxidative stress, Toxicity of Perchloroethylene, Trichloroethylene, 1,1,1-trichloroethane, and Methylene Chloride to Fathead Minnows, Perchloroethylene and Dry Cleaning: Its Time to Move the Industry to Safer Alternatives, Human Health Effects of Tetrachloroethylene: Key Findings and Scientific Issues, NIOSH: Tetrachloroethylene, Neurobehavioural effects of developmental toxicity, Long-term Neurotoxic Effects of Early-life Exposure to Tetrachloroethylene-contaminated Drinking Water
Acetone is a colorless, flammable liquid that dissolves in water and has a distinct smell and taste. It is also known as dimethyl ketone, 2-propanone, and beta-ketopropane. This manufactured chemical, which is used to create plastic, fibers, drugs, and other chemicals, can also be found in the environment in plants, trees, volcanic gases, forest fires, vehicle exhaust, tobacco smoke, and landfill sites, with industrial processes contributing more to its presence than natural ones. Acetone can be harmful if absorbed through the skin or inhaled, potentially causing irritation to the skin and respiratory tract, as well as adverse effects on the central nervous system (CNS), liver, and kidneys. The allowable exposure limit is set based on its potential to cause eye and upper respiratory irritation and CNS impairment.
Diethanolamine is a chemical found in various consumer products like shampoos, cosmetics, and pharmaceuticals. Acute exposure in humans can result in irritation of the nose, throat, and skin. However, no detailed data is available on its chronic, reproductive, developmental or carcinogenic effects on humans. Studies on animals reveal that acute oral exposure can influence the liver, blood, kidney, and central nervous system, while dermal exposure has been connected with an increased incidence of liver and kidney tumors in mice. Production of first-degree burns, skin irritation, occupational asthma, kidney, and liver injury risk, and potential skin sensitization are some other adverse effects associated with diethanolamine.
Chemical Safety Facts: Ethanolamines, NTP Toxicology and Carcinogenesis Studies of Diethanolamine, California Environmental Protection Agency: Diethanolamine , International Agency for Research on Cancer: Diethanolamine, Initial List of Hazardous Air Pollutants with Modifications, What is the Toxics Release Inventory?, OPINION CONCERNING DIALKYL- AND DIALKANOLAMINES AND THEIR SALTS IN COSMETIC PRODUCTS, Ethanolamine Compounds (MEA, DEA, TEA And Others), WHAT ARE ETHANOLAMINE COMPOUNDS (DEA, MEA, OR TEA): CHEMICAL FREE LIVING, The Dirty Dozen: DEA-related ingredients, FDA: Diethanolamine, Chemical Profile: Diethanolamine ,
Diethylene glycol ethers is a chemical that has been found to have hematologic, liver, and kidney effects. Exposure to large amounts, about 250 mg/kg/day, can lead to central nervous system depression and other organ damage in rats and may decrease red blood cell counts. It does not show genotoxic, mutagenic, liver, kidney, blood, or reproductive toxicity in animals or humans, but it is classified as an exceptional allergen. The material can be absorbed through the skin and is identified as a mild skin irritant and a severe eye irritant. Notably, its toxicity is lower than that of ethylene glycol ethers.
Methyl ethyl ketone (MEK), is a manufactured chemical found naturally in some trees, fruits, and vegetables, and is released from vehicle exhausts. The colorless liquid with a sharp, sweet odor is primarily used in paints, coatings, glues, and as a cleaning agent due to its quick evaporation and solubility properties. Human exposure can result in irritation to the eyes, nose, throat, and long-term inhalation can cause mild neurological, liver, kidney, and respiratory effects in animals. Developmental effects like decreased fetal weight and malformations have been observed in mice and rats. While the EPA has not classified it for human carcinogenicity, it is listed as a potential substance for narcotic abuse by inhalation by the U.N. International Drug Control Programme due its potential to cause Central Nervous System depression.
2-Aminoethanol is a colorless, viscous liquid that, despite not being registered for pesticide use in the U.S, holds vast potential in a variety of applications. It can be used in cutting fluids, production of soaps, surfactants, salts, corrosion control inhibitors, pharmaceuticals, and even in protective topical solutions against chemical warfare agents. Used as a pharmaceutical adjuvant, 2-Aminoethanol is effective as a solvent for fats and oils and in creating emulsion formulas like lotions and creams. However, it poses health risks, as a 5.9% concentration can irritate human skin and inhalation may cause allergic reactions, liver damage, and liver symptoms.
Hydrochloric acid is used in multiple industries like chlorides, fertilizers, dyes, electroplating, and others. It has dangerous health effects like irritation and inflammation of eyes, nose and respiratory tract, and pulmonary edema after short-term inhalation; corrosion to mucous membranes, esophagus, and stomach and severe burns after oral exposure; dermatitis, photosensitization, gastritis and chronic bronchitis after long-term occupational exposure. While the EPA hasn't classified hydrochloric acid for carcinogenicity, many chemicals can spill to release HCl in water.
Phosphoric acid, in liquid or solid form, can cause second-degree burns upon contact within minutes. It's usually shipped as a solid or an 85% solution and is corrosive to skin when the concentration is over 70%. This acid is also an irritant to the eyes, skin, and upper respiratory tract, however, the risk of pulmonary edema is minimal.
Sodium hydroxide, also known as caustic soda or lye, is an odorless white crystalline solid that absorbs moisture from the air. It generates significant heat when dissolved in water or neutralized with acid which may ignite combustible materials. It is highly corrosive and is typically used as a solid or in a 50% solution. Sodium hydroxide is used to manufacture a variety of products including soaps, rayon, paper, explosives, dyestuffs, and petroleum products. Exposure to this substance may cause severe burns, necrosis, and pulmonary edema, depending on the concentration and exposure method.
Potassium hydroxide 30-70% is a liquid that is highly corrosive to skin, causing second or third-degree burns even after brief contact. It is a hazardous substance that can also induce pulmonary edema, a condition characterized by excessive fluid in the lungs. The effects and properties of this chemical can be compared to those of Sodium hydroxide.
Triethanolamine appears to cause occupational asthma and allergic contact dermatitis in machinists and photographers, as well as liver and kidney damage in animals with high-dose feeding. It's noted to be an irritant to the skin, eyes, and respiratory tract, with potential to cause skin sensitization, though the rate of skin sensitization in humans is low. Triethanolamine has low acute toxicity, with median oral LD50 values of 4,190-11,260 mg/kg in rats and 5,300-8,000 mg/kg in guinea pigs, and a median dermal LD50 greater than 2,000 mg/kg in rabbits. Triethanolamine is not carcinogenic, developmental toxicant, or toxic to the reproductive system. However, chronic exposure may lead to liver and kidney damage.
Safety assessment of triethanolamine and triethanolamine-containing ingredients as used in cosmetics, Toxicology of mono-, di-, and triethanolamine, Campaign for Safe Cosmetics: Ethanolamine Compounds (MEA, DEA, TEA And Others), The Dirty Dozen: DEA-related ingredients, Chemical Profile, Special Chem, Safety assessment of triethanolamine and triethanolamine-containing ingredients as used in cosmetics
Ethanolamine is a liquid that can cause first-degree burns on short exposure. It is known to be a skin irritant and can cause allergic contact dermatitis. Occupational exposure, notably among hairdressers, has been linked to asthma. Inhalation of ethanolamine in high concentrations can lead to Central Nervous System (CNS) depression and can be toxic to the liver, as shown in subchronic inhalation studies in animals. It is also a skin, eye, and respiratory tract irritant, with the potential to sensitize the skin.
Toluene is a clear, colorless liquid that naturally occurs in crude oil and the tolu tree. It's prominent in the production of gasoline, coke from coal, and various consumer products like paints, adhesives, and nail polish. Toluene is even added to gasoline, used to create benzene, and acts as a solvent. However, exposure to toluene, especially from inhalation, can have serious health effects. It primarily targets the central nervous system, inducing symptoms like fatigue, nausea, headaches, and in chronic cases, can cause severe dysfunction. Exposure has also been linked to developmental effects in children, but there isn't enough evidence to conclude its carcinogenic potential. Abuse of toluene can cause permanent brain damage, liver injury, and even potential birth defects or increased risk of spontaneous abortions in pregnant women. Despite these risks, cognitive deficits from toluene exposure below a threshold limit value (TLV) of 50 ppm remain extremely low.
Methylisothiazolinone can reportedly cause allergic contact dermatitis in workers who interact with products containing it. This substance is recognized as a contact allergen for consumers using cosmetics that include it. It can cause skin burns and sensitization, and inhaling it may lead to corrosive injuries in the upper respiratory tract and lungs. Ingesting this substance is harmful, and inhalation is toxic. This preservative is linked to the category of isothiazolinones.
Antimicrobial agents, triclosan, chloroxylenol, methylisothiazolinone and borax, used in cleaning had genotoxic and histopathologic effects on rainbow trout, Methylisothiazolinone toxicity and inhibition of wound healing and regeneration in planaria, Methylchloroisothiazolinone and/or methylisothiazolinone in cosmetic products, Isothiazolinone Biocides: Chemistry, Biological, and Toxicity Profiles, Methylisothiazolinone and isothiazolinone allergy, Analysis of isothiazolinones in environmental waters by gas chromatography–mass spectrometry, Methylisothiazolinone induces apoptotic cell death via matrix metalloproteinase activation in human bronchial epithelial cells, EU REGULATIONS , Methylisothiazolinone contact allergy: a review, Effects of methylisothiazolinone and octylisothiazolinone on development and thyroid endocrine system in zebrafish larvae, Two Cases of Chloromethylisothiazolinone and Methylisothiazolinone-associated Toxic Lung Injury, An update of the risk assessment for methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) with focus on rinse-off products, Effects of a mixture of chloromethylisothiazolinone and methylisothiazolinone on peripheral airway dysfunction in children, Isothiazolinone preservative: cause of a continuing epidemic of cosmetic dermatitis, Campaign for Safe Cosmetics: Methylisothiazolinone and Methylchloroisothiazolinone
Benzene is a colorless, sweet-smelling, highly flammable liquid that evaporates quickly into the air and slightly dissolves in water. It's a byproduct of both natural processes and human activities, used extensively in the U.S production of other chemicals for plastics, resins, nylon, rubbers, lubricants, dyes, detergents, drugs, and pesticides. Present in crude oil, gasoline, and cigarette smoke, benzene is also released into the air from burning coal, oil, gasoline stations, and vehicle exhaust. Short-term exposure may cause drowsiness, dizziness, and irritation, while long-term exposure leads to blood disorders, reproductive effects, and even leukemia. Benzene has been classified by EPA as a known human carcinogen, and regulations apply to various industry sectors with potentially high exposure risks.
Diethylene glycol ethers is a chemical that has been found to have hematologic, liver, and kidney effects. Exposure to large amounts, about 250 mg/kg/day, can lead to central nervous system depression and other organ damage in rats and may decrease red blood cell counts. It does not show genotoxic, mutagenic, liver, kidney, blood, or reproductive toxicity in animals or humans, but it is classified as an exceptional allergen. The material can be absorbed through the skin and is identified as a mild skin irritant and a severe eye irritant. Notably, its toxicity is lower than that of ethylene glycol ethers.
Diethylene Glycol Monoethyl Ether, when administered orally or through the skin in doses exceeding 800-1000 mg/kg/day, can cause central nervous system depression and changes to the liver and kidneys in animals. However, it doesn't exhibit significant developmental toxicity at these levels. The chemical is not expected to have adverse effects unless workers are exposed to its heated liquid mists. It is an eye irritant and provokes harm to the central nervous system, liver, kidneys, red blood cells, and reproductive system in animal feeding studies. Despite these potential harms, it is poorly absorbed through the skin.
Ethylene glycol is a synthetic, odorless liquid with a sweet taste and water absorption properties. It is commonly used in antifreeze and de-icing solutions for vehicles, hydraulic brake fluids, and certain inks. Although lethal in large ingested quantities, leading to central nervous system depression, cardiopulmonary effects, and renal damage, exposure to low levels can cause minor throat and upper respiratory tract irritation. Chronic exposure in animals has demonstrated kidney toxicity and liver effects. Despite its potential toxicity, ethylene glycol poisoning is unlikely through skin contact and inhalation at room temperature due to its low volatility, though caution should be taken if the liquid is heated or sprayed.
Glutaraldehyde is a colorless, sharp-smelling oily liquid used for a variety of purposes, such as disinfection, sterilization of surfaces, oil and gas recovery, waste water treatment, x-ray processing, leather tanning, paper production, and as chemical intermediate for various other materials. It can also be found in select products like paint and laundry detergent. Although widely used, Glutaraldehyde can cause several health issues, including effecting asthma, allergic contact dermatitis, irritation to skin and respiratory tract, and in high concentrations, toxic hepatitis in mice. It's known to cause severe irritation to eyes and skin, and even small vapor concentrations can result in throat and nose irritation. Reports suggest that it was connected to 9% of work-related asthma cases among healthcare workers over a five-year period.
Glycolic Acid is corrosive to the skin and eyes, with 70% technical solutions causing severe burns. It also irritates the respiratory tract and may lead to kidney failures. The chemical can cause burns when inhaled, leading to possible injuries to the upper respiratory tract and lungs. It is also harmful if ingested.
5-chloro-2-methyl-4-isothiazolin-3-one (CMI) is a compound frequently used as a preservative in cosmetics, hygiene products, and other industrial applications such as hydraulic fracturing fluids. It can also be deployed as a pesticide in the U.S, pending regulatory approval. CMI, which is often used in combination with 2-methyl-4-isothiazolin-3-one (MI), can cause contact dermatitis in humans. Various animal studies have shown that a high exposure to a CMIT/MIT mixture can cause alterations in rats' liver function. The production and use of CMI in a range of products mean it can be release into the environment, with some susceptibility to degradation through photolysis in sunlight. Its mobility in soil is high but volatilization from soil or water surfaces is not expected to be significant. Occupational and general exposure to CMI can occur especially through inhalation and dermal contact with CMI-containing products.
Antimicrobial agents, triclosan, chloroxylenol, methylisothiazolinone and borax, used in cleaning had genotoxic and histopathologic effects on rainbow trout, Methylisothiazolinone toxicity and inhibition of wound healing and regeneration in planaria, Methylchloroisothiazolinone and/or methylisothiazolinone in cosmetic products, Isothiazolinone Biocides: Chemistry, Biological, and Toxicity Profiles, Methylisothiazolinone and isothiazolinone allergy, Analysis of isothiazolinones in environmental waters by gas chromatography–mass spectrometry, Methylisothiazolinone induces apoptotic cell death via matrix metalloproteinase activation in human bronchial epithelial cells, EU REGULATIONS , Methylisothiazolinone contact allergy: a review, Effects of methylisothiazolinone and octylisothiazolinone on development and thyroid endocrine system in zebrafish larvae, Two Cases of Chloromethylisothiazolinone and Methylisothiazolinone-associated Toxic Lung Injury, An update of the risk assessment for methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) with focus on rinse-off products, Effects of a mixture of chloromethylisothiazolinone and methylisothiazolinone on peripheral airway dysfunction in children, Isothiazolinone preservative: cause of a continuing epidemic of cosmetic dermatitis, Campaign for Safe Cosmetics: Methylisothiazolinone and Methylchloroisothiazolinone
Nonylphenol ethoxylate, commonly found in cleaning products, has been linked to allergic contact dermatitis among workers. It is a strong eye irritant, causing mild to severe eye irritation, possible corneal injury, and mild skin irritation. Inhalation can be harmful. It has been shown to cause changes in liver functions and have demonstrated effects on the liver, kidney, and fetus at doses that are toxic to mothers (maternally toxic) in non-mammalian species. Despite these effects, there is no reported teratogenicity, carcinogenicity, or skin sensitization associated with nonylphenol ethoxylate in experimental animals and human studies.